The dihydropryimidin-imines are having wide range of biological activities. The synthesis of potential substituted dihydropryimidin-imines by different methods among them the major ones are microwave irradiation, phase transfer catalyst and using biocatalyst. The comparison of these methods to get an efficient and ecofriendly way for synthesis of bigenelli dihydropryimidin-imines. The different study shows different catalyst used for the efficient synthesis of dihydropryimidin-imines. The one pot synthesis was also studied in comparison with microwave irradiation and phase transfer catalyst. Among them usage of biocatalyst was found not only efficient and ecofriendly but also short reaction time. This review focus on synthesis methods which is environmentally safe and less time consuming with minimum quantity of reagents.
This publication contributes to global health by exploring novel compounds with antimicrobial potential, supporting efforts to combat infectious diseases. By evaluating sustainable synthesis methods, the research advances innovation in pharmaceutical sciences while promoting environmentally responsible practices. The findings strengthen the scientific foundation for developing safer, faster, and greener approaches to drug discovery, aligning with global goals for health, innovation, and sustainability.
